PLU-1 is a member of the JARID1 family of Jumonji C histone demethylases and specifically demethylates the diand trimethylated forms of Lys4 in histone H3 (H3K4me2/3). Demethylation of H3K4me2/3 by PLU-1 silences the expression of genes that regulate cell cycle progression in breast cells, promoting invasive cancer. These findings have been corroborated by mouse model studies demonstrating that the activity of PLU-1 is essential to cell proliferation, suggesting that PLU-1 ...
PLU-1 is a member of the JARID1 family of Jumonji C histone demethylases and specifically demethylates the diand trimethylated forms of Lys4 in histone H3 (H3K4me2/3). Demethylation of H3K4me2/3 by PLU-1 silences the expression of genes that regulate cell cycle progression in breast cells, promoting invasive cancer. These findings have been corroborated by mouse model studies demonstrating that the activity of PLU-1 is essential to cell proliferation, suggesting that PLU-1 ...
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