Targeted protein phosphorylaytion is a key event that serves to transduce DNA damage induced cell signals from upstream sensors to downstream effectors. ATR kinase phosphorylates BRCA1 and Rad17 upon DNA damage. Furthermore, the phosphorylation of BRCA1 can also influence the phosphorylation of other substrates by ATR. As a first approach to evaluate the functional consequence of IR-induced site-specifically phosphorylated residues on BRCA1, we have established a BRCA1-dependent transcription based assay ...
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