CENTRALLY ACTING ALPHA2-ADRENERGIC COMPOUNDS SUCH AS MEDETOMIDINE, SHOW ANTIHYPERTENSIVE ACTIONS WITH SEDATIVE PROPERTIES. RECENTLY WE HAVE SHOWN THAT A NAPHTHALENE ANALOG OF MEDETOMIDINE, IS ALSO A VERY POTENT AND SELECTIVE ALPHA2-ADRENERGIC STIMULANT. IT HAS BEEN SPECULATED THAT THE QUINOXALINE NITROGENS OF THE POTENT AND SELECTIVE A2-ADRENERGIC AGONIST, UK14,304, ARE INVOLVED IN THE BINDING TO THE RECEPTORS. HOWEVER, THE DRUG-RECEPTOR INTERACTION IN THIS SERIES IS NOT UNDERSTOOD AND HAS NOT BEEN ...
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