Quantitative RT-PCR and immunohistochemistry (IHC) experiments revealed that membrane-type serine protease 1 (MT-SPl), a member of the TTSP family, is specifically overexpressed in epithelial cancer cells and tissue samples. It was reported that in advanced stages of prostate, breast, and ovarian cancers MT-Spl is not regulated by its endogenous inhibitor HAI-l. MT- Spl plays diverse roles by activating pro-uPA, pro-HGF, and PAR-2. Taken together, MT-SPl may be a key upstream ...
Early studies revealed the importance of MT-SP1 in prostate cancer progression and indicated the existence of other serine proteases involved in the cascade. Developing selective and potent protease inhibitors is challenging due to frequent coexpression of other similar proteases. The antibody scaffold is an attractive choice for the development of highly potent and selective inhibitors. A phage-displayed antibody library was screened against a cancer- associated protease membrane-type serine protease 1 ...
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