Toxicity commonly occurs after exposure to a variety of chemicals agents. Changes in gene expression are among the most sensitive indicators of chemical exposure. Toxicogenomics, which is based on DNA microarray technology, is the study of the cellular response to chemical insults at the transcriptomic level by simultaneous measurement of the expression levels of virtually all expressed genes. Therefore, this technology is a useful technique for studying the molecular mechanism ...
Toxicogenomic profiling is a molecular approach to capture the global, transcriptomic response of a biological system caused by perturbations resulted from chemical exposure. Coupled with advanced bioinformatic techniques, it allows for the elucidation of the molecular mechanisms of chemical toxicity, as well as the identification of novel biomarkers predictive for chemical exposure. In an effort to investigate if gene expression changes in whole blood can serve as novel biomarkers indicative ...
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