| ERG Expression Levels in Prostate Tumors Reflect Functional Status of the Androgen Receptor (AR) as a Consequence of Fusion of ERG with AR Regulated Gene Promoters |
Jan 2010 |
9 pages |
| Authors:
Albert Dobi; Bungo Furusato; Syed Shaheduzzaman; Yongmei Chen; Maryanne Vahey; Timothy Nydam; Isabell A Sesterhenn; David G McLeod; Gyorgy Petrovics; Shiv Srivastava; UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
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 | Expression of the ERG proto-oncogene, is activated in 50-70% of prostate tumors by androgen receptor (AR) mediated signals due to the fusion of AR regulated promoters (primarily TMPRSS2 and to a lesser extent SLC45A3 and NDRG1) to the ERG protein coding sequence. Our previous studies of quantitative expression levels of ERG or TMPRSS2-ERG fusion transcripts have noted that relatively low or no ERG expression in prostate tumors significantly associated with ... |
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| HBCU Summer Undergraduate Training Program in Prostate Cancer Research |
Aug 2009 |
25 pages |
| Authors:
Shiv Srivastava; HENRY M JACKSON FOUNDATION ROCKVILLE MD
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| In first year of the award, four meritorious students were selected for HBCU Summer Undergraduate Training Program in Prostate Cancer Research by USU-CPDR and UDC selection committee. The students were assigned to the faculty members of USU, focusing on specific research projects in basic science and database research. The ongoing projects in prostate cancer research provide them with knowledge, expert guidance and tools to successfully complete the assignments. Student and ... |
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| HBCU Summer Undergraduate Training Program in Prostate Cancer Research |
Aug 2011 |
43 pages |
| Authors:
Shiv Srivastava; HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
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| The goal of this award was to provide prostate cancer (CaP) research summer internships to the students of the University of the District of Columbia (UDC) at the Uniformed Services University of the Health Sciences (USU)-Center for Prostate Disease Research (CPDR). The main objective was to expose students to stimulating research environment that would encourage them to pursue research or medical careers in prostate cancer or relevant biomedical fields. During ... |
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| Structure and Function of the Splice Variants of TMPRSS2-ERG, a Prevalent Genomic Alteration in Prostate Cancer |
Sep 2009 |
30 pages |
| Authors:
Shiv Srivastava; HENRY M JACKSON FOUNDATION ROCKVILLE MD
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| Characterization of major TMPRSS2-ERG splice variants in prostate cancer specimens for the first time provides information on the full length protein coding sequences of TMPRSS2-ERG fusion transcripts which is urgently needed in developing more precise bio-marker and therapeutic strategies. Unexpected discovery on predominance of type II splice variants e.g., TMPRSS2-ERG8 and identification of novel splice variants: TMPRSS2-EPC1 and TMPRSS2-EPC2 represents the unique outcome of this grant effort focusing on unbiased ... |
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| Structure and Function of the Splice Variants of TMPRSS2-ERG, a Prevalent Genomic Alteration in Prostate Cancer |
Sep 2011 |
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| Authors:
Shiv Srivastava; HENRY M JACKSON FOUNDATION ROCKVILLE MD
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| The most common early genetic defect in prostate cancer (CaP) is the TMPRSS2-ERG gene fusion that results in the expression of the ERG protooncogene. In the context of rearranged genome ERG is transcribed under the control of the androgen inducible TMPRSS2 promoter producing cancer-associated splice variants of ERG. Although, much has been learned in recent years about gene fusions in prostate cancer, the function of TMPRSS2-ERG splice variants is not ... |
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| Structure and Function of the Splice Variants of TMPRSS2-ERG, a Prevalent Genomic Alteration in Prostate Cancer |
Sep 2012 |
85 pages |
| Authors:
Shiv Srivastava; HENRY M JACKSON FOUNDATION ROCKVILLE MD
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| We hypothesized that specific ERG splice forms in TMPRSS2-ERG fusion transcripts are selectively expressed in CaP cells and are functionally relevant in CaP. The specific aims of this study were to characterize full length sequences of TMPRSS2-ERG transcripts; to quantitatively evaluate selected TMPRSS2-ERG variants in CaP specimens and their prognostic features; and to defined the functional significance of specific splice variants of the rearranged ERG locus in CaP. We have ... |
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