| Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer |
JAN 2005 |
68 pages |
| Authors:
Sarah Spiegel; VIRGINIA COMMONWEALTH UNIV RICHMOND
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 | Lysophosphatidic acid (LPA) is a major mitogen in serum that regulates an array of cellular processes related to pathogensis of cancer, especially ovarian, prostate and breast cancer. Interest in LPA has accelerated recently with the discovery that it is a ligand of a family of three G protein coupled cell surface receptors. Prostate cancer cells express these LPA receptors and it has been suggested that their expression correlates with more ... |
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| Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer |
JAN 2004 |
59 pages |
| Authors:
Sarah Spiegel; VIRGINIA COMMONWEALTH UNIV RICHMOND
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| Originally known for its pedestrian role as an intermediate in intracellular lipid metabolism, LPA is now recognized as a potent lipid mediator that evokes growth-factor-like responses and regulates an array of cellular processes related to pathogenesis of cancer. These include stimulating proliferation by increasing cell cycle progression, enhancing cell survival, stimulating motility and inducing tumor cell invasion, and regulating neovascularization. Progress in understanding LPA actions has accelerated with the discovery ... |
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| Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer |
JAN 2003 |
58 pages |
| Authors:
Sarah Spiegel; VIRGINIA COMMONWEALTH UNIV RICHMOND
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| Lysophosphatidic acid (LPA) is a major mitogen in serum that regulates an array of cellular processes related to pathogenesis of cancer, especially ovarian, prostate and breast carcinomas. LPA stimulates proliferation by increasing cell cycle progression and suppression of apoptosis, as well as enhancing tumor cell invasion and angiogenesis (1, 2). Several reports have shown that LPA can transactivate the EGF tyrosine kinase receptor (3-5) by stimulating metalloproteinase processing of proHB-EGF ... |
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| Role of Sphingosine Kinase in Radiation-Induced Apoptosis of Human Prostate Cancer Cells |
AUG 2000 |
55 pages |
| Authors:
Victor Nava; Sarah Spiegel; GEORGETOWN UNIV WASHINGTON DC MEDICAL CENTER
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| Understanding the biological mechanisms that control cell growth and cell death is a mayor goal in cancer research since it could allow the design of anti-neoplasic therapies to specifically eliminate tumor cells. The effectiveness of radiotherapy and chemotherapy relies in pant in their ability to induce a genetic program of cell destruction know as apoptosis. Unfortunately, at present this conventional therapies induce cell death of both normal and cancer cells ... |
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