TNF related apoptosis inducing ligand, TRAIL, is a recently cloned cytokine that has been shown to induce apoptosis in a synergistic fashion with chemotherapeutic agents on several cancer cell lines. Xenografts of several carcinoma cell lines demonstrate TRAIL and chemotherapy to cause complete regression of established tumors. Etoposide, a topoisomerase type II inhibitor, induces the upregulation of TRAIL in several breast and lung carcinoma lines, Analysis of human lung tumors ...
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