The objective of this work was to determine the dose-response relationship between the duration of a topical exposure of sulfur mustard vapors to hairless guinea pigs (HGPs) and the incidence of microblisters observed histologically. The dose-response curve was compared to results of similar work performed at the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD). The effects of ketamine hydrochloride anesthesia on HGP skin reflectance were also examined. The ...
Surgical production of the isolated, perfused porcine skin flap (IPPSF) model involved resection and suturing of an area of inguinal skin to form a tubular flap. Two days after production, the flap was cannulated and perfused in an environmentally controlled chamber. The objective of this work was to establish the IPPSF technology at Battelle for examining the dermatotoxicity of topically applied sulfur mustard (HD) and for assessing candidate countermeasures. Data ...
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