Allen Singer - Storming Media

Transition and Use of the Mouse Ear Model for Evaluating Candidate Pre- and Post-Treatrnents for Efficacy Against Percutaneous Sulfur Mustard Exposure at the Medical Research and Evaluation Facilit

APR 2000

58 pages

Authors: Carl T. Olson; Robyn Kiser; James Blank; Marie Moore; Allen Singer; BATTELLE MEMORIAL INST COLUMBUS OH

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The mouse ear model has been used at the U.S. Army Medical Institute of chemical Defense (USAMRICD) to assess dermal injury caused by sulfur mustard (HD) and to evaluate potential pre- and posttreatment compounds for efficacy against percutaneous HD injury. In this model, the effects of HD with or without treatment compounds are evaluated macroscopically by edema and microscopically by histopathological changes associated with HD injury. ...