| Regulation of Breast Carcinoma Progression by the Alpha-6 Integrins |
OCT 2001 |
72 pages |
| Authors:
Leslie M. Shaw; A. Mercurio; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
 | During this career development award, I have made significant progress in determining the contribution of the alpha 6 beta 1 integrin receptors to breast cancer. We had previously established that the alpha 6 beta 1 receptor contributes to the growth and survival of breast carcinoma metastases. In addition, we had demonstrated that de novo expression of the integrin beta 4 subunit in breast carcinoma cell lines that lack this integrin ... |
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| Regulation of Breast Carcinoma Progression by the Alpha-6 Integrins |
SEP 2000 |
14 pages |
| Authors:
Leslie M. Shaw; A. Mercurio; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| During the third year of this career development award, we have continued to make progress in determining the contribution of the alpha6 integrin receptors to breast carcinoma progression. In previous work we had established that the alpha6Beta1 receptor contributes to the growth and survival of breast carcinoma metastases. In addition, we had demonstrated that expression of the Beta4 integrin subunit in breast carcinoma cell lines that lack this integrin subunit ... |
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| Regulation of Breast Carcinoma Progression by the Alpha-6 Integrins |
SEP 1999 |
73 pages |
| Authors:
Leslie M. Shaw; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| During the second year of this career development award, we have continued to make progress in determining the contribution of the alpha6 integrin receptors to breast carcinoma progression. In previous work we had established that the alpha6Beta4 receptor contributes to the growth and survival of breast carcinoma metastases. In addition, we had demonstrated that de novo expression of the integrin Beta4 subunit in breast carcinoma cell ... |
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| Regulation of Breast Carcinoma Progresssion by the Integrins |
SEP 1998 |
23 pages |
| Authors:
Leslie M. Shaw; BETH ISRAEL HOSPITAL BOSTON MA
|
| During the first year of this career development award, we have made progress in determining the contribution of the alpha-6 integrin receptors to breast carcinoma progression. In previous work we had established that the alpha-6-Beta-1 receptor contributes to the growth and survival of breast carcinoma metastases. In addition, we had demonstrated that de novo expression of the integrin Beta-4 subunit in breast carcinoma cell lines that lack this integrin subunit ... |
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| The Role of Integrin Signaling in Breast Cancer |
OCT 1997 |
19 pages |
| Authors:
Leslie M. Shaw; BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
|
| During this fellowship award, I made considerable progress in understanding the contribution of the alpha6 integrin receptors to breast carcinoma progression. I developed a dominant negative strategy to knock-out' the expression of the alpha6beta1 integrin in a highly metastatic breast carcinoma cell line (MDA-MB-435). After depletion of alpha6beta1 surface expression, these cells are deficient in their growth in the mammary fat pad of athymic mice and can no longer survive ... |
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Reports by Author
