Award DAMD-99-l-9367 seeks to understand the role of membrane trafficking in Epidermal Growth Factor Receptor (EGER) signal transduction. We have been using a tissue culture model system (HeLa cells) to isolate the activated EGER at distinct stages in the endocytic pathway. Our research has focused on rab5, a small molecular weight GTPase, implicated in the biogenesis of the early endosome. Mutations to modulate the guanine nucleotide binding properties of this ...
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