The purpose of this proposal is to understand the molecular pathways regulating Bcr-Abl positive CML cells. We demonstrated that the transcription factor, CREB, is highly expressed in K562 cells and cells from patients with chronic phase CML. This led us to hypothesize that CREB may play a critical role in regulating proliferation of CML cells. To determine whether CREB and CREB-dependent pathways may be bonafide targets for CML therapy, we ...
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