Alterations in the coagulation and complement systems during Rocky Mountain spotted fever (RMSF) were studied in Macaca mulatta experimentally infected with Rickettsia rickettsii. Ninety-one percent of monkeys infected iv with a high dose and 56% of monkeys infected with low doses of rickettsiae died after two to four days of illness. With the onset of fever and rickettsemia, animals developed hyperfibrinogenemia, mild thrombocytopenia, prolonged prothrombin and activated partial thromboplastin times, ...
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