Algorithms predicting tissue and blood partition coefficients (PCs) from solvent properties (octanol:water, saline or water:air, oil:air coefficients) were compared to assess their usefulness for a petroleum mixtures physiologically based pharmacokinetic/pharmacodynamic model. Measured blood:air and tissue:blood PCs were sought from literature resources for 14 JP-8 components. PCs, mainly from vial equilibration experiments, were separated by species (rat and human) and averaged by tissue and chemical. Average experimental PCs were then compared ...
Exposures to JP-8 can occur from vapor, liquid or aerosol. Inhalation and dermal are the most prevalent routes of exposure, and acute effects include neurobehavioral deficits. Occupational exposures of interest include aircraft fuel tank workers and exhaust workers. JP-8 is a complex mixture of hundreds of components including straight chain alkanes, branched chain alkanes, cycloalkanes, diaromatics and napthalenes. A first step to developing a physiologically-based pharmacokinetic (PBPK) model for JP-8 ...
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