| The Effects of Ricin on the Heart and Coronary Arteries |
01 FEB 95 |
189 pages |
| Authors:
Casey P. Robinson; OKLAHOMA UNIV OKLAHOMA CITY COLL OF MEDICINE
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 | Effects of ricin on rabbit heart, coronary arteries, and distribution of blood flow to various organs and tissues were investigated. Ricin increased cardiac output, and blood flow to most organs/tissues. Ricin was given 0.22 micrograms/kg and 48 hours later changes were determined. Ricin decreased sensitivities of coronary arteries to 5-HT- and histamine contractions, increased sensitivity to NE relaxations, increased maximal contractions, but did not alter ACh-induced relaxations. Ricin increased basal ... |
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| The Effects of Ricin on the Heart and Coronary Arteries |
20 JAN 94 |
69 pages |
| Authors:
Casey P. Robinson; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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| The effects of giving rabbits a minimal lethal dose (0.22 ug/kg) of ricin on their hearts and coronary arteries were investigated. Ricin did not alter the time to peak tension of the papillary muscle and its contraction duration, or frequency responses. The EC50 for force development of the papillary muscle in the presence of Bay K 8644 was increased by ricin. Ricin did not alter the resting membrane potential, action ... |
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| Antidotes for Ricin Intoxication. Effects of Ricin on the Vascular Neuroeffector System |
25 OCT 92 |
187 pages |
| Authors:
Casey P. Robinson; Victoria J. Christiansen; Chia-Hsuh Hsu; Lin Zhang; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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| The i.v. 48 hour (and 7 day) LD50 and the minimum lethal dose (MLD) of ricin in male New Zealand White rabbits has been determined by the Up and Down procedure. A MLD and a toxic sub-lethal dose (TSD) lowered blood pressure after a 12 hour or greater lag period, but only the MLD did so significantly (p < 0.05). Heart rate was increased when blood pressure was reduced, which ... |
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| Soman Effects on the Vascular Neuroeffector System |
01 MAY 90 |
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| Authors:
Casey P. Robinson; Chao-Yu Hu; Chia-Hsuh Hsu; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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 | The effects of soman on the vascular system were examined in rabbits. Soman injection caused a slight decrease in core body temperature 1 hour after injection, but temperature had returned to normal 23 hours later. This soman dose also caused a fall in both systolic and diastolic blood pressure 1 hour and 24 hours after treatment with soman. Body weights were slightly decreased on the first 3 days of injections, ... |
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| Lack of an Effect of Saxitoxin on the Contractility of Isolated Guinea Pig Trachea, Lung Parenchyma and Aorta |
14 FEB 89 |
19 pages |
| Authors:
Casey P. Robinson; David R. Franz; Maria E. Bondura; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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| The effects of saxitoxin were investigated in guinea pig tracheal rings, lung parenchymal strips and aorta rings. Tracheal rings were used both with epithelium present and with it removed. Aorta rings were used both with endothelium present and with it removed. Saxitoxin, 1 picomole to 0.1 micro mole, did not alter the resting tension of either airway tissues or aorta. Also, 0.1 micro mole saxitoxin did not reduce tension of ... |
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| Agent Effects on the Vascular Neuroeffector System |
01 MAY 87 |
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| Authors:
Casey P. Robinson; Chao-Yu Hu; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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| The effects of soman on the resting contractile tension of human uterine arteries and on the contractions of these arteries to vasoactive agents were investigated. Soman did not alter the resting tension of helically cut strips of human uterine arteries. Soman did not alter concentration-response curves of the strips to norepinephrine, serotonin, potassium chloride, or histamine. Soman increased contractile tension of human uterine artery strips to subsequently added 1 micromole ... |
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| Agent Effects on the Vascular Neuroeffector System |
01 MAY 86 |
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| Authors:
Casey P. Robinson; Chao-Yu Hu; Chia-Yao Hung; OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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| The effects of soman, a cholinesterase inhibitor, on the vascular system were examined in rabbits. Soman injection caused a slight decrease in core body temperature 1 hour after injection, but temperature had returned to normal 23 hours later. Body weights were slightly decreased the first 3 days of injections, but weights were not significantly different from controls on any of the days. A sublethal dose of soman caused a fall ... |
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| Reactions of Methamidophos with Mammalian Cholinesterase, |
JUL 1978 |
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| Authors:
Casey P. Robinson; Donald Beiergrohslein; Paul W. Smith; Charles R. Crane; FEDERAL AVIATION ADMINISTRATION WASHINGTON D C OFFICE OF AVIATION MEDICINE
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| The lethality of methamidophos, a phosphoramidothioate, to rats (i.p. LD50, 15 mg/kg), is similar to that of such potent organophosphate compounds as parathion and paraoxon. Certain distinctive features of its chemical structure, and reported failure of cholinesterase inhibited with methamiodophos to reactivate spontaneously in insects, prompted this study of its reactions with mammalian cholinesterase to determine if the treatment of poisoning requires modification. Atropine (10 mg/kg) or pralidoxime (60 mg/kg) ... |
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| The Role of Monamine Oxidase Inhibition in The Acute Toxicity of Chlordimeform, |
AUG 1977 |
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| Authors:
Paul W. Smith; Casey P. Robinson; Jane D. Zelenski; Boyd R. Endecott; FEDERAL AVIATION ADMINISTRATION WASHINGTON D C OFFICE OF AVIATION MEDICINE
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| This paper presents data from experiments on male rats performed to determine whether drugs which interfere with central amine mechanisms would decrease the lethality of the acaricide chlordimeform (and thus be of potential value as antidotes for accidental poisoning) or increase chlordimeform lethality (and thus should be avoided by aerial applicators and others in contact with it). Neither reducing serotonin synthesis with p-chlorophenylalanine, raducing norepinephrine synthesis with DL-alpha-methyl-p-tyrosine nor depleting ... |
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