One goal this research project has been to assess the dependence of breast cancer cell survival on the P13 kinase/Akt signaling pathway. This signaling pathway is hypothesized to be critical to breast cancer survival especially under growth-limiting conditions or when chemotherapeutics are present. Using a series of six breast cancer cell lines and a phenotypcially normal, but immortal, breast line I first determined the baseline level of phosphorylated Akt as ...
Th the past year I have assessed the dependence of breast cancer cell survival on the P13 kinase/Akt pathway. The ability of cells to survive under adverse conditions, such as when growth factors are limited or when chemotherapeutics are present, likely contributes to the progression of breast cancer. Using six breast cancer cell lines and one immortal, but phenotypically normal, breast line, I first looked at the ability of each ...
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