We proved the major hypothesis driving this project that effective regression of breast cancer growth and metastases can be achieved by suppressing tumor angiogenesis with an orally delivered DNA-based vaccine carried by double attenuated Salmonella typhimurium. For this approach, the murine vascular endothelial growth factor receptor-2 (FLK-1) proved to be an effective target. We also targeted the inhibitor of apoptotic protein, surviving, and endoglin and achieved a similar protection against ...
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