The objective is to use adjuvants to enhance the immunogenicity of a dengue (DEN) DNA vaccine. The adjuvants to be evaluated in this project included aluminum phosphate, tetanus toxoid and anti-Fc R monoclonal antibodies chemically linked to the DNA vaccine. Multiple attempts to link the anti-Fc R monoclonal antibody to the DNA vaccine resulted in a poor efficiency in the linkage reaction using thiol linkage chemistry. An alternative approach using ...
The objective is to use adjuvants to enhance the immunogenicity of a dengue (DEN) DNA vaccine. The adjuvants to be evaluated in this project include aluminum phosphate, tetanus toxoid and anti-Fc(gamma)R monoclonal antibodies chemically linked to the DNA vaccine. Multiple attempts to link the anti-Fc(gamma)R monoclonal antibody to the DNA vaccine resulted in a poor efficiency in the linkage reaction using thiol linkage chemistry. An alternative approach using hydrazine and ...
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