The central aim of this research is to provide information on the neurochemical processes that underlie the generation and entrainment of mammalian circadian rhythms. The studies are centered around the newly-developed in vivo brain microdialysis technique for assessing the daily patterns of neurotransmitter release in the suprachiasmatic nuclei (SCN) of freely-behaving hamsters. During the funded period, this approach has yielded several new findings related to the activities of serotonergic and ...
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