This project was designed to identify novel integrin ligands that are expressed in breast cancer tissue, by studying members of the MDC protein family. As a model system for breast cancer progression, we are using transgenic mice that express the polyomavirus middle T oncogene in the mammary gland epithelium Using the polymerase chain reaction (PCR), we have shown that MDC9 and MDCl5 are expressed in mammary tumor tissue derived from ...
The goal of this project is to identify members of the MDC protein family that are expressed in breast cancer tissue, to develop novel antibodies to them, and to determine their distribution in tumor tissue as well as in cultured breast cancer cell lines. As a model system for breast cancer progression, we are using transgenic mice that express the polyomavirus middle T oncogene in the mammary gland epithelium. Using ...
Protein families known to be important in regulating tissue architecture and cell behavior include integrins, cadherins, Ig-CAMS, collagens, proteoglycans, tenascins, thrombospondins, matrix metalloproteases (MMPs), and many others. However, there are additional protein families that are likely to be important, but thus far have not been investigated with respect to their distribution and function in mammary tumors. One of these is a recently recognized family of transmembrane proteins containing integrin-binding domains, ...
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