Chad K Porter - Storming Media

Volunteer Challenge With Enterotoxigenic Escherichia coli That Express Intestinal Colonization Factor Fimbriae CS17 and CS19

01 Jul 2011

6 pages

Authors: Robin McKenzie; Chad K Porter; Joyce A Cantrell; Barbara DeNearing Aisling; Shannon L Grahek; Stephanie A Sincock; Colleen Woods; Peter Sebeny; David A Sack; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD ENTERIC DISEASES DEPT

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Human challenges with enterotoxigenic Escherichia coli (ETEC) have broadened our understanding of this important enteropathogen. We report findings from the first challenge studies using ETEC-expressing colonization factor fimbria CSI7 and CSI9. LSN03-016011/A (LT, CS17) elicited a dosedependent effect, with the upper dose (6 X 10(exp 9) organisms) causing diarrhea in 88% of recipients. WS0115A (LTSTp, CSI9) also showed a dose response, with a 44% diarrhea rate at 9 X 10(exp ...

The Incidence and Gastrointestinal Infectious Risk of Functional Gastrointestinal Disorders in a Healthy US AduIt PopuIation

Jan 2011

10 pages

Authors: Chad K Porter; Robert Gormley; David R Tribble; Brooks D Cash; Mark S Riddle; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD

Functional gastrointestinal disorders (FGDs) are recognized sequelae of infectious gastroenteritis (IGE). Within the active duty military population, a group with kn own high IGE rates, the population based incidence, risk factors, and attributable burden of care referable to FGD after IGE are poorly defined.

The Epidemiology of Infectious Gastroenteritis Related Reactive Arthritis in U.S. Military Personnel: A Case-Control Study

13 Sep 2010

26 pages

Authors: Jennifer A Curry; Mark S Riddle; Robert P Gormley; David R Tribble; Chad K Porter; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD ENTERIC DISEASES DEPT

Background. Reactive arthritis (ReA) is a recognized sequela of infectious gastroenteritis (IGE). However, the population-based incidence of IGE-related ReA is poorly defined, and the risk of disease has not previously been characterized in a military population. The intent of this study was to provide estimates of the incidence and morbidity associated with IGE-related ReA in the U.S. military population. Methods. Using active duty US military medical encounter data from the ...

The Epidemiology of Travelers' Diarrhea in Incirlik, Turkey: A Region with a Predominance of Heat-Stabile Toxin Producing Enterotoxigenic Escherichia coli

Jan 2010

9 pages

Authors: Chad K Porter; Mark S Riddle; David R Tribble; Shannon D Putnam; David M Rockabrand; Robert W Frenck; Patrick Rozmajzl; Edward Kilbane; Ann Fox; Richard Ruck; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD ENTERIC DISEASES DEPT

This study evaluated travelers' diarrhea among US military personnel on short term deployment to lncirlik Air Base. Turkey from June through September 2002. Upon reporting for care for travelers'diarrhea, subjects were enrolled into the study and completed a series of questionnaires and provided stool specimens for pathogen identification and antimicrobial susceptibility testing. Fifty-three percent of the 202 participating subjects had a pathogen isolated from their stool. Entcrotoxigenic Escherichia coli (ETEC) ...

The Epidemiology of Guillain-Barre Syndrome in U.S. Military Personnel: A Case-Control Study

26 Aug 2009

8 pages

Authors: Laura Nelson; Robert Gormley; Mark S Riddle; David R Tribble; Chad K Porter; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD ENTERIC DISEASES DEPT

Background: Guillain-Barre Syndrome (GBS), the leading cause of acute flaccid paralysis worldwide, is an autoimmune disorder involving the loss of the myelin sheaths encasing peripheral nerve axons, leading to a loss of nerve signaling and typically ascending paralysis. A number of infectious triggers have been identified, with Campylobacter being most common. Limited data are available regarding GBS in U.S. service members at a high risk of exposure to numerous GBS-associated ...

The Effect of Trihalomethane and Haloacetic Acid Exposure on Fetal Growth in a Maryland County

29 Mar 2005

12 pages

Authors: Chad K Porter; Shannon D Putman; Katherine L Hunting; Mark R Riddle; NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD ENTERIC DISEASES DEPT

As water flows from treatment plants to the tap, chlorine, used to disinfect surface water meant for residential use, reacts with residual organic and inorganic matter, creating chlorine disinfection by-products. In recent years, these by-products have been scrutinized as a potential reproductive and developmental hazard. This study examined whether exposure to the four total trihalomethanes or the five haloacetic acids (two major subgroups of chlorine disinfection by-products) was related to ...