The most significant conclusion that is going to be derived from the work on this proposal is the relationship of tumor cell contribution to the extra cellular environment and tumor growth. This was unexpected when we started this proposal and this work has not been completed. However, based on the findings generated in this DOD proposal Dr. Plymate has received a 5 yr NCI/NIH U54 Program Project to further develop ...
The hypothesis of this proposal is that: The mac25/lGFBP-rpl gene functions as a tumor suppressor for prostate epithelium by induction of additional genes regulating response to oxidative stress, senescence, and differentiation. One of these, SOD2, impairs tumor cell growth by detoxifying superoxides which may initiate transformation, or by interaction with growth promoting signal pathways via modulation of protein phosphorylation. Another, SOX9, induces a subset of genes required for differentiation of ...
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