We compared the effect of order of administration of investigational alphavirus vaccines on neutralizing antibody response. Volunteers who received the inactivated eastern and western equine encephalitis (EEE and WEE) vaccines before live attenuated Venezuelan (VEE) vaccine had significantly lower rates of antibody response than those receiving VEE vaccine before EEE and WEE vaccines (66.7% vs. 80.6%; p=0.026). The odds of having a VEE antibody non-response among those initially receiving EEE ...
We studied early temporal gene expression in human peripheral blood mononuclear cells after in vitro infection with Francisella tularensisi live vaccine strain. Recently, investigators from Sweden studied ulceroglandular tularemia by gene expression profiling of blood from patients with active ongoing infection. Host responses to tularemia were described in their study of several potential genes as biomarkers for early tularemia. Most of the host genes related to tularemia were confirmed in ...
Immunization protects the personal health of United States military personnel and maintains their mission readiness. The immunization program of the U.S. Department of Defense (DoD) is broad-ranging, protecting the forces from an array of pathogenic threats. Because the active and reserve components of the U.S. DoD consist of over 2.2 million people at any given time, the program immunizes a significant percentage of the U.S. adult population. This article updates ...
A broad range of health effects in a cohort of 601 health rare personnel, immunized with anthrax vaccine adsorbed (AVA) as a military occupational health requirement, were assessed to evaluate adverse events both qualitatively and quantitatively. Active surveillance showed that localized reactions were common and occurred more often in women than men. five patients were reported to the Vaccine Adverse Event Reporting System, hut only one event could he definitively ...
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