Rebecca Pitotti - Storming Media

Intraosseous Hydroxocobalamin in the Treatment of Acute, Severe Cyanide Induced Cardiotoxicity in a Swine (Sus Scrofa) Model - An Alternate Administration Route for Chemical Mass Casualties

05 Apr 2012

7 pages

Authors: Vikhyat Bebarta; Julio Lairet; Rebecca Pitotti; Susan Boudreau; Toni Vargas; Patricia Dixon; Tylan Muncy; AIR FORCE MEDICAL WING (59TH) WILFORD HALL MEDICAL CENTER LACKLAND AFB TX

The full text of this report is available for sale.

To compare the rerum to baseline of mean arterial blood pressure (MAP) between 2 groups of swine in acute cyanide toxicity and treated with IV HOC or 10 HOC. We also compared blood cyanide, lactate, pH, nitrotyrosine levels, cerebral oxygenation, and inflammatory markers. 24 swine (48-52kg) were intubated, anesthetized, and instrumented (MAP and cardiac output (CO) monitoring). Cyanide was continuously infused until severe hypotension (50 per cent of baseline MAP). ...

Sodium Thiosulfate Versus Hydroxocobalamin in the Treatment of Acute, Severe Cyanide Induced Cardiotoxicity in a Swine (Sus Scrofa) Model

22 Sep 2011

4 pages

Authors: Vikhyat Bebarta; Julio Lairet; Rebecca Pitotti; Patricia Dixon; Sandra Valtier; Anneke Bush; AIR FORCE MEDICAL WING (59TH) WILFORD HALL MEDICAL CENTER LACKLAND AFB TX EMERGENCY MEDICAL SERVICES

To compare the return to baseline of mean arterial blood pressure (MAP) between 3 groups of swine with acute CN toxicity and treated with HOCOB, ST, or a combination of HOCOB+ST. 36 swine ( 48-52kg) were intubated, anesthetized, instrumented and then poisoned with a continuous CN infusion, until the development of severe hypotension (Time 0-50% of baseline MAP). Animals were randomly assigned to the groups and monitored for 60 min ...