Vitamin a derivatives (retinoids) are known to be potent regulators of cell proliferation and epithelial cell differentiation and specifically inhibit the growth of several cancers. The mechanisms of action of retinoids are just starting to be understood. For example, retinoids are known to inhibit the junction of AP-1, a transcription factor complex that is involved in cell proliferation and neoplastic transformation. Retinoids are also known to stabilize components of the ...
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