| Action of Cholinergic Poisons on the Central Nervous System and Effectiveness of Potential Antidotes |
01 DEC 86 |
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| Authors:
Fred Samson; Stanley R. Nelson; Thomas Pazdernik; KANSAS UNIV MEDICAL CENTER KANSAS CITY
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 | This report describes the actions of soman on brain in the rat experimental animal model and the effectiveness of eight different antidotal pretreatments. The behavior, local cerebral glucose use (LCGU), brain muscarinic receptor and histology are described for the seizure phase (1 hr. after soman), neuropathology phase (72 hr after soman) and recovery phase (10 days after soman). Antidotes studied were representatives from five different classes: muscarinic receptor blockers, nicotinic ... |
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| Action of Cholinergic Poisons on the Central Nervous System and Effectiveness of Potential Antidotes |
DEC 86 |
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| Authors:
Fred Samson; Stanley R. Nelson; Thomas Pazdernik; KANSAS UNIV MEDICAL CENTER KANSAS CITY
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| The aims were to identify the effects of soman on rat brain and the extent of protection by antidotes atropine, benactyzine, scopolamine, physostigmine, physostigmine, pyridostigmine, mecamylamine, pralidoxime, diazepam. The behavior, local cerebral glucose use (LCGU), brain muscarinic receptors and histology were studied for both seizure phase (1 hr after exposure) and neuropathology phase (72 hr after exposure). As we reported previously, soman induces prolonged convulsions associated with large LCGU increases ... |
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| Action of Cholinergic Poisons on the Central Nervous System and Effectiveness of Potential Antidotes |
DEC 85 |
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| Authors:
Fred Samson; Stanley R. Nelson; Thomas Pazdernik; KANSAS UNIV MEDICAL CENTER KANSAS CITY
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| The aims were to identify the effects of soman on rat brain and the extent of protection by the antidotes atropine, benactyzine, scopolamine, physostigmine, pyridostigmine, mecamylamine, pralidoxime, diazepam. The behavior, local cerebral glucose use (LCGU), brain muscarinic receptors and histology were studied for both seizure phase (1 hr after exposure) and neuropathology phase (72 hr after exposure). As we reported previously, soman induces prolonged convulsions associated with large LCGU increases ... |
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| Action of Cholinergic Poisons on the Central Nervous System and Effectiveness of Potential Antidotes |
DEC 85 |
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| Authors:
Fred Samson; Thomas Pazdernik; Stanley Nelson; KANSAS UNIV MEDICAL CENTER KANSAS CITY
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| Soman is a powerful seizure-inducing agent, and thus, it is important to understand its impact on the central nervous system during seizures and the effectiveness of antidotes against soman intoxication. This report describes findings in experimental animals (rats) on the brain regions involved during soman-induced seizures and postseizure phases. Further, it compares soman seizures with those induced by the excitotoxin kainic acid and the gamma- aminobutyric acid (GABA) receptor blocker ... |
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| Action of Cholinergic Poisons on the Central Nervous System and Effectiveness of Potential Antidotes |
FEB 84 |
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| Authors:
Fred Samson; Stanley R. Nelson; Thomas Pazdernik; KANSAS UNIV MEDICAL CENTER KANSAS CITY
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| The effects of soman and other cholinergic poisons on the structure and function of the brain were studied in rats. Quantitative autoradiography was used to detect changes in local cerebral glucose use (LCGU; 2-deoxyglucose technique) and cholinergic receptors. Major findings reported are: 1) Soman produces continuous, long-lasting seizures, associated with large increases in LCGU in most brain regions. 2) Soman-induced seizures are followed by conspicuous neuropathology (e.g. piriform cortex, amygdala) ... |
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