Discovery of novel mammary developmental and cancer genes using ENU mutagenesis This project seeks to discover new genes involved in mammary gland carcinogenesis, by screening for reduced latency to palpable mammary tumors in response to the myc oncogene, that is produced by the loss of a second gene knocked out by random ENU mutagenesis. This project draws upon the large scale recessive ENU mutagenesis project at the John Curtin School ...
Mammary lobuloalveolar development during pregnancy is controlled by the endocrine action of prolactin, estrogen and progesterone, but currently little is known of the transcriptional events that occur in response to these hormones. This study examines the transcriptional response of the mammary gland to the direct action of prolactin. Mammary tissue recombination experiments demonstrated that lobuloalveolar development is dependent upon the presence of prolactin receptors in mammary epithelium but not the ...
Discovery of novel mammary developmental and cancer genes using ENU mutagenesis. The rate of death from breast cancer has only begun to fall in recent years To dramatically reduce breast cancer death rates we need new therapeutic targets, currently a major challenge facing cancer researchers This requires an understanding of the undiscovered pathways that operate to drive breast cancer cell proliferation, cell survival and cell differentiation, pathways which are also ...
A screen of the first round of large scale mutagenesis has been completed. Six pedigrees with members harboring mammary tumors were identified. These pedigrees were recreated from genetic backups and are now being screened using mammary biopsy. Affected females will be used to establish stable breeding lines.
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