| Trichothecene Mycotoxin Studies |
21 NOV 87 |
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| Authors:
M. A. Marletta; P. M. Newberne; A. E. Rogers; W. R. Roush; G. N. Wogan; MASSACHUSETTS INST OF TECH CAMBRIDGE
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 | The major objectives of this research contract were to examine the in vitro and in vivo metabolism of anguidine (diacetoxyscirpenol) in rodents as well as to detail the pathological effects of this toxin on target tissues, with the ultimate goal of devising effective intervention protocols by treatment with potential protective agents. A chemistry research component was included to provide radiolabeled anguidine for metabolism studies, to structurally elucidate anguidine metabolites produced ... |
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| Trichothecene Mycotoxin Studies |
25 AUG 86 |
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| Authors:
M. A. Marletta; P. M. Newberne; A. E. Rogers; W. R. Roush; G. N. Wogan; MASSACHUSETTS INST OF TECH CAMBRIDGE
|
| The major objectives of this research contract are to examine the in vitro and in vivo metabolism of anguidine (diacetoxyscirpenol) in rodents as well as to detail the pathologic effects of this toxin on target tissues, with the ultimate goal of devising effective intervention protocols by treatment with potential protective agents. A chemistry research component has been included to provide radiolabeled anguidine for metabolism studies, to structurally elucidate anguidine metabolites ... |
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| Trichothecenes Mycotoxin Studies |
FEB 86 |
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| Authors:
G. H. Buchi; M. A. Marletta; P. M. Newberne; A. E. Rogers; W. R. Roush; MASSACHUSETTS INST OF TECH CAMBRIDGE
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| The purposes of the research supported under this contract are to determine the toxicity of two members of the tricothecene mycotoxins, (anguidine, (das) and nivalenol) including their gross and microscopic effects; absorption, distribution and excretion by several routes of administration; to identify and synthesize the more prominent metabolites, and to identify or synthesize compounds which will block or reduce the toxicity of DAS and nivalenol. During the past year we ... |
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| Trichothecenes Mycotoxin Studies |
DEC 85 |
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| Authors:
G. H. Buchi; M. A. Marletta; P. M. Newberne; A. E. Rogers; W. R. Roush; MASSACHUSETTS INST OF TECH CAMBRIDGE
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| The purposes of the investigations conducted under this contract were to: 1) establish the precise nature and distribution of injury to biological systems by diacetoxyscirpenol (DAS; anguidine); 2) determine the major metabolites by using in vitro and in vivo systems and with different routes of exposure in the latter; 3) determine major forms of products excreted by rodents; 4) to synthesize or otherwise acquire substances which may offer protection from ... |
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| Tricothecenes Mycotoxin Studies |
SEP 84 |
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| Authors:
G. H. Buchi; M. A. Marletta; P. M. Newberne; A. E. Rogers; W. R. Roush; MASSACHUSETTS INST OF TECH CAMBRIDGE
|
| The purposes of the research supported under this contract are to determine the toxicity of two members of the tricothercene mycotoxins, (anguidine, (DAS) and nivalenol) including their gross and microscopic effects; absorption, distribution and excretion by several routes of administration; to identify and synthesize the more prominent metabolites, and to identify or synthesize compounds which will block or reduce the toxicity of DAS and nivalenol. During the past year we ... |
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| Tricothecenes Mycotoxin Studies |
SEP 1983 |
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| Authors:
G. H. Buchi; M. A. Marletta; P. M. Newberne; A. E. Rogers; W. R. Roush; MASSACHUSETTS INST OF TECH CAMBRIDGE
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| The purposes of the research are to elucidate the metabolism and toxicity of tricothecene mycotoxins, identify and synthesize their active metabolites and identify and synthesize compounds to block or reduce their toxicity. An efficient procedure for purification of anguidine has been developed to provide uniformly pure samples for all phases of the program. Tritiated anguidine has been prepared for use in metabolic studies, and metabolites have been synthesized for use ... |
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