| New Hybrid Route to Biomimetic Synthesis |
21 MAR 2003 |
76 pages |
| Authors:
Daniel E. Morse; CALIFORNIA UNIV REGENTS SANTA BARBARA OFFICE OF RESEARCH
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 | To develop economical low-temperature routes to biomimetic synthesis of high-performance composite materials, with control of composition and structure based on the molecular mechanisms controlling biomineralization of calcium- and silicon-based nanocomposites. HIGHLIGHTS: We report success in our originally proposed transition from analysis of biological systems to the development of useful applications across a broad range of materials. We discovered that the silicateins - proteins we originally discovered responsible for the structure-directing ... |
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| Biological Rules and Mechanisms Governing the Nanofabrication of Highly Regular Mineralized Microlaminate Composites |
10 OCT 2000 |
5 pages |
| Authors:
Daniel E. Morse; Galen D. Stucky; Paul K. Hansma; CALIFORNIA UNIV SANTA BARBARA
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| We purified and characterized the proteins from the microlaminate abalone shell (a natural high performance armor with fracture toughness 3,000- fold greater than that of its mineral component alone) and "flat pearl" and from sponge and diatom biosilicas. We then cloned and sequenced the cDNAs encoding these proteins, and used the resulting structural information, in concert with site- directed mutagenesis (genetic engineering) and real-time atomic force ... |
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| Molecular Marine Symbiosis |
30 SEP 91 |
4 pages |
| Authors:
Daniel E. Morse; CALIFORNIA UNIV SANTA BARBARA MARINE SCIENCE INST
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| We advance both our in vitro dissection of the molecular mechanisms controlling larval attachment and metamorphosis of the mollusc, Haliotis rufescens, and our characterization of the molecular adhesive and the mechanisms controlling fouling by the cementing polychaete, Phragmatopoma Californica. Our results Show that the chemosensory mechanisms and the internal signal transducers mediating the induction of larval attachment and metamorphosis in both Phragmatopoma and Haliotis larvae are highly related at the ... |
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| Ocean Environmental and Surface Parameters Controlling Initial Events in Macrofouler Recruitment |
31 JAN 91 |
4 pages |
| Authors:
Daniel E. Morse; CALIFORNIA UNIV SANTA BARBARA MARINE SCIENCE INST
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| The principal long term objective of this project was to identify and characterize those environmental, biological, and surface parameters that control the initial and rate-limiting processes of larval settlement, attachment, metamorphosis, growth and recruitment of macrofouling organisms on surface immersed in the ocean. Macrofouling of surfaces immersed in the ocean is initiated by the delivery and attachment of larvae or propagules from the plankton. Work in our laboratory conducted with ... |
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| Molecular Mechanisms of Chemosensory Receptors, Signal Transducers, and the Activation of Gene Expression Controlling Establishment of a Marine Symbiosis |
31 OCT 90 |
6 pages |
| Authors:
Daniel E. Morse; CALIFORNIA UNIV SANTA BARBARA MARINE SCIENCE INST
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| OBIECTIVE: To characterize the molecular mechanisms by which marine invertebrate larval chemosensory receptors and their associated signal transducers regulate surface attachment and metamorphosis of the larvae in response to chemical signals from the environment; and To characterize the molecular mechanisms regulating the activation of specific gene expression in the developmentally arrested marine invertebrate larva, in response to chemical inducers of metamorphosis. We have found that metamorphosis in larvae of the ... |
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| Molecular Mechanisms of Chemosensory Receptors, Signal Transducers, and the Activation of Gene Expression Controlling Establishment of a Marine Symbiosis |
01 JUL 89 |
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| Authors:
Daniel E. Morse; CALIFORNIA UNIV SANTA BARBARA MARINE SCIENCE INST
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 | We have resolved and analyzed in vitro 10 of the 13 separate molecular reactions and pathways controlling metamorphosis of Haliotis larvae (in response to exogenous signal molecules) that we first identified in vivo. Two different chemosensory receptors and receptor-dependent signal transduction cascades regulating metamorphosis have now been characterized on highly purified cilia from the larval epithelium. The receptors, a receptor-regulated G protein, and proteins phosphorylated by receptor-regulated protein kinases A ... |
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| Molecular Mechanisms of Chemosensory Receptors, Signal Transducers, and the Activation of Gene Expression Controlling Establishment of a Marine Symbiosis |
31 JUL 88 |
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| Authors:
Daniel E. Morse; CALIFORNIA UNIV SANTA BARBARA MARINE SCIENCE INST
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| The first year's progress is reported in our research analyzing the chemical signal receptors, signal transducers, and mechanisms controlling specific gene expression, in the regulation of larval metamorphosis in the marine mollusc, Haliotis rufescens. We have partially purified and begun in vitro characterization of the larval chemosensory receptors and signal transducers controlling metamorphosis in response to exogenous chemical signals. We have cloned and begun sequence analysis of the insulin gene. ... |
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| Biochemical Control of Marine Fouling |
14 JAN 88 |
14 pages |
| Authors:
Daniel E. Morse; CALIFORNIA UNIV SANTA BARBARA MARINE SCIENCE INST
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| Although marine fouling is initiated, in several cases, by the accretion of a thin molecular and microbial layer (microfouling), it is the attachment of larger organisms (macrofouling) that is responsible for the principal increase in drag on vessel hulls, increase in fuel consumption, stress and deterioration of piers, pilings and cassions, and the reduced efficiency of heat-exchangers in the marine environment. Virtually all marine organisms that contribute to macrofouling are ... |
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