The biological function of poly (ADP-R) based on its macromolecular properties is envisaged as a nucleic acid component of a cross linking system capable of promoting or inhibiting the regulatory effect of chromatin proteins on transcription. Two examples, the action of triiodothyronine and of chemical carcinogens illustrate this complex action of the homopolymer functioning as a protein modifier. Although DNA and RNA can be profitably studied in isolated systems without ...
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