The goals of the proposed studies are to show that pulse-release microsphere vaccines consisting of antigen and adjuvant is an effective and efficacious method for inducing protective immune responses, that the approach will require less antigen, fewer immunizations and convenient, safe methods for delivery, and that a single multivalent vaccine will be effective in inducing a protective response against the EE viruses. The specific aims ...
The goals of the proposed studies are to show that pulse-release microsphere vaccines consisting of antigen and adjuvant is an effective and efficacious method for inducing protective immune responses, that the approach will require less antigen, fewer immunizations and convenient, safe methods for delivery, and that a single multivalent vaccine will be effective in inducing a protective response against the EE viruses. The specific aims ...
The overall goal of this contract effort was to determine the effectiveness of microencapsulated vaccines compared to the conventional vaccines in inducing protective immune responses against challenge with the pathogens Venezuelan equine encephalitis (VEE) virus and Bacillus anthracis. The microsphere vaccines were formulated of the biodegradable and biocompatible co- polymer poly(DL-lactide-co-glycolide) (DL-PLG). Formalin-fixed and/or 60Co- inactivated TC-83 VEE virus or protective antigen (PA) of B. anthracis was encapsulated in DL-PLG ...
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