Kulthoum A. Mereish - Storming Media

Toxin-Induced Activation of Rat Hepatocyte Prostaglandin Synthesis and Phospholipid Metabolism

22 DEC 89

20 pages

Authors: Syed M. Naseem; Kulthoum A. Mereish; Rikki Solow; Harry B. Hines; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

The full text of this report is available for sale.

The effects of microcystin-LR a trichothecene (T-2 toxin) and saxitoxin on membrane lipid mediators of inflammatory processes were evaluated in cultured rat hepatocytes. Microcystin-LR significantly stimulated the release of prostacyclin and thromboxane B(2) in a concentration-dependent manner. The trichothecene toxin, T-2, enhanced the release of prostaglandin F(2)a (PGF(2)a) by 24% (p <0.05) and arachidonic acid by 29% (p <0.05); while saxitoxin failed to cause the release of prostaglandins or arachidonic ...