Prion diseases are fatal neurodegenerative diseases of mammals. They are characterized by the conversion of normal prion protein (PrP) to a misfolded conformational state that accumulates as plaques in the brain. The diagnosis of prion diseases relies on the ability to differentiate between normal PrP and its misfolded infectious form. This is difficult to accomplish by traditional testing methods, since it requires discerning between conformational states of a protein that ...
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