The major goal of this research is to study the mechanism of corepressor proteins N-CoR in normal and breast cancer cells. It has been shown that N-CoR is capable of association with antagonist-bound estrogen receptor in the hormone-dependent human breast cancer (Shang et al., 2000). In addition, it has been shown that in the tamoxifen resistant breast cancer cells N-CoR expression level is decreased (Lavinsky et al, 1998). These observations ...
Progesterone regulates diverse aspects of proliferation, differentiation and development of mammary, uterine and nervous tissues. The biological functions of progesterone are mediated through the progesterone receptor (PR) whose transcriptional activities are modulated by corepressors and coactivators. We are interested in studying the interaction between corepressors and PR with a view of evaluating the role of this complex on the pharmacology of progestins and anti-progestins in breast cancer. Our group observed ...
Estrogen is a mitogen in most estrogen receptor (ER) positive breast cancers and anti-estrogens like tamoxifen have been the mainline therapies for these types of cancers. Although patients initially respond well to anti- estrogens, resistant tumors often develop within 5-10 years of treatment. The purpose of this research is to develop mechanistically distinct therapeutics by directly blocking the interaction of ER with interacting coactivators required for its transcriptional activity. We ...
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