The 90-day subchronic oral toxicity of nitroguanidine was evaluated in male and female Sprague-Dawley rats. Nitroguanidine was administered in the diet at dose levels of 0, 100, 316, and 1000 mg/kg/day for 90 days. The addition of nitroguanidine to the diet consistently reduced food consumption and caused significant (p < or = 0.05) increases in water consumption. Significantly (p < or = 0.05) reduced weight gains were observed in the ...
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