In an effort to study chronic toxicity of the nervous system by chemicals, exploration of an animal model of ethanol dependence was examined. Previous work had demonstrated that physical dependence on ethanol could be induced in only a few days. The purpose of this study was to establish the existence of tolerance and to determine the rate of development of tolerance and physical dependence. These results demonstrate that when rats ...
1-3-Butanediol (BD) was tested for its ability to suppress an ethanol withdrawal syndrome. Male Sprague-Dawley rats were rendered physically dependent upon ethanol by intragastric administration of 9-15 g/kg of ethanol per day over a 4-day period. A nonintoxicating dose of BD of 4 g/kg, p.o., administered after elimination of ethanol from the blood was effective against the tremulous and convulsive components in all animals for 1-5 hours. This period of ...
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