The packing of submicrometer sized silica beads inside a microchannel was enabled by a novel method which avoids the complication and limitations of generating a frit using conventional approaches and the restriction of flow using a submicrometer sized weir. A micrometer sized weir and two short columns of 5 m and 800nm silica beads packed in succession behind the weir together functioned as a high pressure frit to allow the ...
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