To metastasize, cancer cells have to break through the basement membrane. Ln-5 is one o f the basement membrane proteins, consisting of three chains a3,B3 and y2. Ln-5 y2 chain continas DIII domain, a functional EGFR ligand, which can be released by MMP processing. It has been suggested by our lab that DIII domain may facilitate cancer progression by preventing anoikis. However, both the increased and decreased expression levels of ...
Cancer cells have to break through basement membrane (BM) to metastasize. Laminin-5 is one of the major components of BM. It is composed of three chains alpha3, beta3 and gamma2. The DIII domain which could be released from Ln-5 gamma2 chain by MMPs processing, can bind to EGFR and activates the downstream signaling pathway. The role of Ln-5 in cancer progression is still unclear. There are paradoxical data in regard ...
To metastasize, cancer cells have to break through basement membrane (BM). Laminin-5 is one of the most abundant BM proteins. It consists of three chains alpha3, beta3 and gamma2. DIII domain, a functional EGFR ligand will be released from Ln-5 2 chain by MMPs processing. It has been suggested by our lab that DIII domain may facilitate cancer progression by preventing anoikis. There are paradoxical data in regard of the ...
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