The primary objective of this project was to develop an animal model to measure possible cognitive deficits resulting from chemotherapy. We have established a rat model of multidose human-equivalent combination chemotherapy using cyclophosphamide methotrexate and 5-fluorouracil (CMF) that recapitulates the physical symptoms of chemotherapy treatment. We investigated the effects of this regimen on learning and memory as well as on the production and survival of new neurons in the hippocampus ...
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