| Mitochondrial Gene Cytochrome b Developmental and Environmental Expression in Aedes aegypti (Diptera: Culicidae) |
Nov 2009 |
10 pages |
| Authors:
Liming Zhao; Julia W Pridgeon; James J Becnel; Gary G Clark; Kenneth J Linthicum; AGRICULTURAL RESEARCH SERVICE GAINESVILLE FL CENTER FOR MEDICAL AGRICULTURAL AND VETERINARY ENTOMOLOGY
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 | Cytochrome b, coded by mitochondrial DNA, is one of the cytochromes involved in electron transport in the respiratory chain of mitochondria. Cytochrome b is a critical intermediate in a mitochondrial death pathway. To reveal whether cytochrome b of the mosquito Aedes aegypti (L.) (Diptera: Culicidae) (AeaCytB) is developmentally regulated, we used real-time quantitative polymerase chain reaction (qPCR) to examine AeaCytB gene expression levels in different developmental stages of Ae. aegypti. ... |
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| A High-Throughput Screening Method to Identify Potential Pesticides for Mosquito Control |
Jan-2009 |
8 pages |
| Authors:
Kenneth J Linthicum; Julia W Pridgeon; James J Becnel; Gary G Clark; AGRICULTURAL RESEARCH SERVICE GAINESVILLE FL CENTER FOR MEDICAL AGRICULTURAL AND VETERINARY ENTOMOLOGY
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| Mosquitoes that transmit human diseases are of major importance to the international public health community. Pesticides remain a major component of integrated programs to control these medically important species. However, very few types of pesticides are currently registered for mosquito control. A high-throughput screening method using first-instar larvae of Aedes aegypti was created and evaluated in our laboratory to quickly screen large numbers of chemicals for activity against mosquitoes. LC50 ... |
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| Satellite Vegetation Index Data as a Tool to Forecast Population Dynamics of Medically Important Mosquitoes at Military Installations in the Continental United States |
Jul-2008 |
9 pages |
| Authors:
Kenneth J Linthicum; Benedict Pagac; Alexandra Spring; Jeri Humphries; Erin Stanwix; Kristin Cobb; Maloney; Edwin W Pak; Compton J Tucker; Assaf Anyamba; Seth C Britch; Francis A Jr; Melissa Miller; AGRICULTURE RESEARCH SERVICE GAINESVILLE FL MOSQUITO AND FLY RESEARCH UNIT
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| The United States faces many existing and emerging mosquito-borne disease threats, such as West Nile virus and Rift Valley fever. An important component of strategic prevention and control plans for these and other mosquito-borne diseases is forecasting the distribution, timing, and abundance of mosquito vector populations. Populations of many medically important mosquito species are closely tied to climate, and historical climate-population associations may be used to predict future population dynamics. ... |
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| Synthesis and Bioassay of Improved Mosquito Repellents Predicted From Chemical Structure |
27-May-2008 |
7 pages |
| Authors:
ZUOQUAN WANG; C D Hall; Novruz G Akhmedov; Dimitar Dobchev; Maia Tsikolia; Svetoslav Slavov; Alan R Katritzky; Gary G Clark; Kenneth J Linthicum; Ulrich R Bernier; FLORIDA UNIV GAINESVILLE DEPT OF CHEMISTRY
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| Mosquito repellency data on acylpiperidines derived from the U.S. Department of Agriculture archives were modeled by using molecular descriptors calculated by CODESSA PRO software. An artificial neural network model was developed for the correlation of these archival results and used to predict the repellent activity of novel compounds of similar structures. A series of 34 promising N-acylpiperidine mosquito repellent candidates (4a-4q') were synthesized by reactions of acylbenzotriazoles 2a-2p with piperidines ... |
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| Topically Applied AaeIAP1 Double-Stranded RNA Kills Female Adults of Aedes aegypti |
May-2008 |
8 pages |
| Authors:
Kenneth J Linthicum; Daniel A Strickman; Julia W Pridgeon; Liming Zhao; James J Becnel; Gary G Clark; AGRICULTURAL RESEARCH SERVICE GAINESVILLE FL CENTER FOR MEDICAL AGRICULTURAL AND VETERINARY ENTOMOLOGY
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| Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control in recent years. As a part of our effort to develop new insecticides to control mosquitoes, an inhibitor of apoptosis protein 1 gene in Aedes aegypti (AaeIAP1) was targeted ... |
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| Cytochrome c Gene and Protein Expression: Developmental Regulation, Environmental Response, and Pesticide Sensitivity in Aedes aegypti |
May-2008 |
9 pages |
| Authors:
Kenneth J Linthicum; Julia W Pridgeon; Liming Zhao; James J Becnel; Gary G Clark; AGRICULTURAL RESEARCH SERVICE GAINESVILLE FL CENTER FOR MEDICAL AGRICULTURAL AND VETERINARY ENTOMOLOGY
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| Cytochrome c is a highly conserved protein that is found in many multicellular and unicellular organisms. Cytochrome c is a critical intermediate in apoptosis: a controlled form of cell death that kills cells as part of their natural process of development and in response to environmental condition. To detect whether cytochrome c of the mosquito Aedes aegypti (L.) (AeaCytC) is developmentally regulated, we used quantitative real-time polymerase chain reaction (PCR) ... |
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| Vector Competence of Selected African Mosquito (Diptera: Culicidae) Species for Rift Valley Fever Virus |
01-Jan-2008 |
9 pages |
| Authors:
Michael J Turell; Kenneth J Linthicum; Lisa A Patrican; F G Davies; Alladin Kairo; Charles L Bailey; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD VIROLOGY DIV
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| Outbreaks of Rift Valley fever (RVF) in Egypt, Yemen, and Saudi Arabia have indicated the potential for this disease to spread from its enzootic areas in sub-Saharan Africa. Because little is known about the potential for most African mosquito species to transmit RVF virus (RVFV), we conducted studies to determine the vector competence of selected African species of mosquitoes for this virus. All eight species tested (Aedes palpalis (Newstead), Aedes ... |
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| Susceptibility of Aedes aegypti, Culex quinquefasciatus Say, and Anopheles quadrimaculatus Say to 19 Pesticides with Different Modes of Action |
Jan-2008 |
7 pages |
| Authors:
Kenneth J Linthicum; Julia W Pridgeon; James J Becnel; Gary G Clark; Roberto M Pereira; Sandra A Allan; AGRICULTURAL RESEARCH SERVICE GAINESVILLE FL CENTER FOR MEDICAL AGRICULTURAL AND VETERINARY ENTOMOLOGY
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| To access the relative potency of pesticides to control adult mosquitoes, 19 pesticides with various modes of action were evaluated against Aedes aegypti, Culex quinquefasciatus Say, and Anopheles quadrimaculatus Say. On the basis of 24-h LD50 values after topical application, the only pesticide that had higher activity than permethrin was fipronil, with LD50 values lower than permethrin for 107-, 4,849-, and 2-fold against Ae. aegypti, Cx. quinquefasciatus Say, and An. ... |
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| Mosquito and Fly Control Research by the USDA-ARS Center for Medical, Agricultural and Veterinary Entomology (CMAVE) in the Deployed War-Fighter Protection (DWFP) Program |
May-2007 |
5 pages |
| Authors:
Kenneth J Linthicum; Chris Geden; Miriam Cooperband; Gary Clark; Seth Britch; Ulrich Bernier; James Becnel; Donald Barnard; Sandra Allan; Jerome Hogsette; AGRICULTURAL RESEARCH SERVICE GAINESVILLE FL CENTER FOR MEDICAL AGRICULTURAL AND VETERINARY ENTOMOLOGY
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| Despite existing measures to prevent and control arthropod-borne diseases in military units, these diseases continue to be serious threats to deployed troops. Due to a shrinking list of safe, cost-effective pesticides for control of disease vectors, new and improved toxicants and methods for delivery are needed by the armed forces. Since 2004, the USDA Agricultural Research Service (ARS) has participated in the Department of Defense (DOD) - sponsored Deployed War-Fighter ... |
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| Structure-Activity Relationships of 33 Piperidines as Toxicants Against Female Adults of Aedes aegypti (Diptera: Culicidae) |
Mar-2007 |
8 pages |
| Authors:
Kenneth J Linthicum; James J Becnel; Gary G Clark; Roberto M Pereira; Julia W Prodgeon; Kumudini M Meepagala; AGRICULTURAL RESEARCH SERVICE GAINESVILLE FL CENTER FOR MEDICAL AGRICULTURAL AND VETERINARY ENTOMOLOGY
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| Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control in recent years. As a part of our collaborative effort to search for new insecticides to control mosquitoes, piperidine was used as base compound for further optimization. Herein, we ... |
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| A Revision of the Argyritarsis Section of the Subgenus Nyssorhynchus of Anopheles (Diptera: Culicidae) |
Jan 1988 |
172 pages |
| Authors:
Kenneth J Linthicum; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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| Some of the most important anopheline vectors of malaria in the neotropical faunal region are members of the subgenus Nyssorhynchus. In the Argyritarsis Section of Anopheles (Nyssorhynchus) there are 18 available specific names. This revision recognizes 8 of these nominal taxa as valid biological species, based on the study on 7,659 specimens: 1,355 males, 212 male genitalia, 3,490 females, 1,724 larvae, 878 pupae, among which 607 were individual rearings. Species ... |
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