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Frances S Ligler


Click on the titles below to find US government-authored or -collected reports written by Frances S Ligler

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UV Polymerization of Hydrodynamically Shaped Fibers Jan 2011 5 pages
Authors:  Abel L Thangawng; Howell; Peter B Jr; Christopher M Spillmann; Jawad Naciri; Frances S Ligler; NAVAL RESEARCH LAB WASHINGTON DC
The full text of this report is available for sale.Most natural and man-made fibers have circular cross-sections; thus the properties of materials composed of non-circular fibers are largely unexplored. We demonstrate the technology for fabricating fibers with predetermined cross-sectional shape. Passive hydrodynamic focusing and UV polymerization of a shaped acrylate stream produced metre-long fibers for structural and mechanical characterization.


Optimization of Antibody-Conjugated Magnetic Nanoparticles for Target Preconcentration and Immunoassays Jan 2010 10 pages
Authors:  Joshua E Smith; Kim E Sapsford; Weihong Tan; Frances S Ligler; NAVAL RESEARCH LAB WASHINGTON DC CENTER FOR BIOMOLECULAR SCIENCE AND ENGINEERING
The full text of this report is available for sale.Biosensors based on antibody recognition have a wide range of monitoring applications that apply to clinical environmental, homeland security, and food problems. In an effort to improve the limit of detection of the Naval Research Laboratory (NRL) Array Biosensor, magnetic nanoparticles (MNPs) were designed and tested using a fluorescence-based array biosensor. A full optimization study of the antibody-modified MNPs and their use in the biosensor was performed. The results demonstrate ...


Organic Photodiodes for Biosensor Miniaturization Jan-2009 8 pages
Authors:  Jason R Wojciechowski; Max Sonnleitner; Hans J Prall; Christoph Winder; Martin Schamesberger; Roland Pieler; Erwin Fuereder; Mariko Y Yamaguchi; Lisa C Shriver-Lake; Frances S Ligler; NAVAL RESEARCH LAB WASHINGTON DC
The full text of this report is available for sale.Biosensors have successfully demonstrated the capability to detect multiple pathogens simultaneously at very low levels. Miniaturization of biosensors is essential for use in the field or at the point of care. While microfluidic systems reduce the footprint for biochemical processing devices and electronic components are continually becoming smaller, optical components suitable for integration- such as LEDs and CMOS chips-are generally still too expensive for disposable components. This paper describes the ...


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