| Design Issues of a Mind Snaps Implementation |
May-2009 |
16 pages |
| Authors:
Hua Li; Rafael Alonso; SET CORP ARLINGTON VA
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 | The intelligence analysis process consists of a complex, iterative, highly-branched sequence of information gathering and processing steps. Throughout the process, the analyst needs to refer to the hypotheses and information he or she was manipulating at previous points in the process. A key enabler for the analytic process would be to provide analysts with semantic bookmarks, i.e., a mechanism that would allow them to return to a particular point in ... |
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| Case Master |
Apr-2009 |
101 pages |
| Authors:
Hua Li; Rafael Alonso; Sven Brueckner; Andrew Yinger; Philip Bramsen; Liz Downs; Van Parunak; TECHTEAM GOVERNMENT SOLUTIONS INC CHANTILLY VA DIGITAL SUPPORT
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| The CASE MASTER project focused primarily on the development of the InformANTS prototype, a distributed, scalable, and adaptive system that tracks the activities of one or more intelligence analysts, maintains up-to-date models of these analysts' interest, models dynamically changing sets of documents from the web or in InformANTS-enabled wikis, and recommends at any time relevant documents or other analysts to a given user. In the development of the prototype, the ... |
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| Identification of Pro-Differentiation p53 Target Genes and Evaluation of Expression in Normal and Malignant Mammary Gland |
01-Apr-2008 |
36 pages |
| Authors:
Hua Li; DARTMOUTH COLL HANOVER NH
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| Delta-N-p63 plays a critical role in making decision to preserve or forfeit mammary stem cells/progenitor cells self-renewal capacity. In embryonic stem cells, some transcription factors including oct3/4, nanog, c-myc and Klf-4 are critical to maintain self-renewal and multi-potential stasis. Our study revealed that these key transcription factors also exist in adult mammary stem cells/progenitor cells as well as breast cell lines such as IMEC, MCF-10A, SUM102 and MCF- 7 cells. ... |
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| Identification of Pro-Differentiation p53 Target Genes and Evaluation of Expression in Normal and Malignant Mammary Gland |
APR 2007 |
32 pages |
| Authors:
Hua Li; DARTMOUTH MEDICAL SCHOOL HANOVER NH
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| Ectopic delta-N-p63 could block retinoic acid induced differentiation in embryonic carcinoma cells NT2/D1, and preserve transcript level of nestin post RA treatment. Similarly, RA treatment could inhibit the proliferation of breast cancer cell lines, and down-regulate the mRNA level of some self-renew relative genes including oct3/4, nanog and dab2 in these cells. Immunocytoflurescence staining detected existence of delta-N-p63 in both estrogen receptor negative cells such as SUM102, SUM149 and MDA-MB-231 ... |
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| Identification of Pro-Differentiation P53 Target Genes and Evaluation of Expression in Normal and Malignant Mammary Gland |
APR 2006 |
38 pages |
| Authors:
Hua Li; Pratima Cherukuri; Alissa Pho; Victoria Cowling; Michael Cole; Andrew K. Godwin; Wendy Wells; James Direnzo; DARTMOUTH COLL HANOVER NH
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| Tumor stem cell theory implies that causative lesions underlying human malignancies occur and are harbored in multi-potent progenitors with retained proliferative capacity and a prolonged lifespan. Transcriptional profiling of human breast cancers has identified five distinct subtypes of which the basal-epithelial subtype is most aggressive, correlates with poor prognosis, and lacks established molecular targets such as ER alpha, PR and Her2- overexpression. These tumors display a high degree of cellular ... |
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