During the last research period, we have made significant progress in the development of our mouse neu-reactive T cell lines. First, we have confirmed the key CD4+ neu peptides (p101 and p373) most effective at priming T cell responses. Of the peptide-specific T cell lines tested, only p101- and p373- T cells induced both peptide- and protein-specific responses. In preliminary studies involving adjuvants, GMCSF was highly effective for use with ...
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