During the second year of this award, we have implemented three different models of skeletal repair that can be used to assess different strategies of progenitor cells, scaffolds and host preparation used to heal a critical sized defect. GFP reporters harbored in the mice that are used in the models provide a cellular explanation for the outcome and image analytical techniques afford an objective quantization of the results. Continued efforts ...
During the first year of this award, we have demonstrated that mice carrying transgenic GFP reporters that reflect the level of osteoblast differentiation and the host/donor origin of these cells provides a rapid, highly informative and ultimately quantitative interpretation of a transplantation experiment of skeletal stem cells into a critical size bone defect. The calvarial defect model has been the primary platform to test a number of donor cell preparations ...
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