The purpose of the studies conducted in the first reporting period was to begin to investigate the effect of pharmacologicstimulation of A2A or A2B adenosine receptors on trauma/hemorrhagic shock-induced organ injury in rats. The A2A receptoragonist 2-p-(2-carboxyethyl)phenethyl-amino-5'-N-ethyl-carboxamidoadenosine CGS21680 (0.1 and 0.5 mg/kg)exacerbated organ injury when mixed into Ringer s Lactate resuscitation fluid, which was associated with a longlastinghypotensive effect of this agent. In contrast, the A2B receptor agonist BAY 60-6583 ...
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