Two groups of normal young men have been studied by standard renal clearance techniques while undergoing orthostasis. The subjects in Group 1, who were tilted while bearing their own weight, showed a modest decrease in filtration rate and renal plasma flow, and an insignificant change in the maximum reabsorptive capacity for glucose despite profund antidiuresis. The subjects in Group 2, who were tilted passively, manifested a significantly greater decline in ...