The epidermal growth factor receptor (EGFR) is a prototypic receptor tyrosine kinase (RTK) and a member of the ErbB family of receptors. The ErbB receptors and their cognate ligands are frequently overexpressed in human cancers, notably carcinoma of the breast. Unfortunately no known secreted or extracellular ErbB receptor inhibitors have been discovered in mammals. Two natural extracellular inhibitors of the highly homologous Drosophila EGF receptor (dEGFR) have been recently discovered ...
The epidermal growth factor receptor (EGFR) is a member of the erbB family of receptor tyrosine kinases (RTKs). These receptors and their cognate ligands are frequently overexpressed in human tumors, including carcinoma of the breast. No secreted or extracellular ErbB receptor inhibitors have been reported in mammals. However, two natural inhibitors of the highly homologous Drosophila EGF receptor are found in Drosophila melanogaster. My research proposal focuses on obtaining a ...
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