| Development of Medical Countermeasures to Sulfur Mustard Vesication |
17 AUG 2005 |
6 pages |
| Authors:
William J. Smith; Michael C. Babin; Robyn C. Kiser; Robert P. Casillas; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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 | Sulfur mustard (HD) is an alkylating agent with cytotoxic, mutagenic and vesicating properties. It use on the battlefield results in debilitating injuries to skin, eyes and the respiratory system (1, 2). To elucidate the toxic sequelae that follow cutaneous exposure to HD, the United States Army Medical Research Institute of Chemical Defense (USAMRICD) has undertaken a broad-based research program encompassing both intramural and extramural research. This report summarizes our current ... |
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| Crossover Comparison of the Pharmacokinetics of Atropine and Pralidoxime Chloride in Three Multichambered Autoinjector Systems and the Mark I. Task 90-15. |
30 MAR 1991 |
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| Authors:
Carl T. Olson; Garrett S. Dill; Ronald G. Menton; Robyn C. Kiser; Thomas H. Snider; BATTELLE MEMORIAL INST COLUMBUS OH
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 | Eight sheep were injected in a crossover study with four different autoinjectors with at least a 1-week wash out between autoinjectors. The pharmacokinetics of atropine and pralidoxime chloride was used to compare the different autoinjectors against the standard Mark I. Results were normalized for dose since there was significant difference in the doses contained between the different autoinjectors. When two of the autoinjectors (MCA-A and MCA-B) were used, the atropine ... |
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| Characterization of Soman Toxicity in Atropine and Oxime (HI-6 and MMB- 4) Treated Rhesus Monkeys |
30 MAR 1991 |
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| Authors:
Carl T. Olson; Ronald C. Menton; Robyn C. Kiser; M. C. Matthews; Timothy L. Hayes; BATTELLE MEMORIAL INST COLUMBUS OH
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| A study was instituted to characterize in rhesus monkeys the toxicity, based on lethality, morbidity, and pathology, of GD when exposure was followed by treatment with atropine and either of two test oximes, HI-6, and MMB-4. The 48 hour LD-50 was determined for untreated monkeys and monkeys treated with atropine/HI-6 and atropine MMB-4. HI-6 was significantly more effective than MMB-4 in treating GD intoxication. The times to death were significantly ... |
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| An Efficacy and Pharmacokinetic Evaluation of a Dose of Diazepam That Will Reduce the Incidence of Convulsions in Indian Rhesus Monkeys Pretreated with Pyridostigmine Bromide, Challenged with Soman, and Treated with Atropine and Pralidoxime Chloride with |
DEC 1990 |
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| Authors:
Carl T. Olson; Garrett S. Dill; Ronald G. Menton; Robyn C. Kiser; Timothy L. Llayes; BATTELLE MEMORIAL INST COLUMBUS OH
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| A study was initiated to determine the smallest dose of diazepam that would result in no more than a 20 percent incidence of convulsions in male rhesus monkeys pretreated with pyridostigmine, challenged with soman, and post treated with atropine and 2-PAM in conjunction with diazepam. Additionally, the pharmacokinetic parameters for diazepam in monkeys were determined using the effective dose of diazepam determined in the efficacy portion. The estimated 90 min ... |
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