C. A. KNUPP - Storming Media

FATE AND DETECTION OF T-2 TOXIN AND ITS METABOLITES AS INFLUENCED BY DOSAGE, ROUTE OF ADMINISTRATION, SPECIES AND THERAPEUTIC INTERVENTION. ANALYTICAL METHODOLOGY.

DEC 1986

Authors: STEVEN P. SWANSON; H. DEAN ROOD; C. A. KNUPP; CARLA HELASZEK; ROSEANN MCCARTNEY; ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND FORT DETRICK MD

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THIS STUDY LOOKED AT THE INFLUENCE OF DOSAGE, ROUTE OF ADMINISTRATION, SPECIES AND THERAPEUTIC INTERVENTION IN DETERMINING THE FATE AND DETECTION OF T-2 TOXIN IN RATS AND PIGS. THE ANALYSES INCLUDED ANALYSIS OF DEXAMETHASONE, DIAGNOSTIC SCREENING METHOD FOR DETECTION OF TRICHOTHECENE EXPOSURE, MASS SPECTRA OF TRICHOTHECENE MYCOTOXINS, GAS CHROMATOGRAPHY OF TRICHOTHECENES, THERMOSPRAY HPLC/MS, AND RAMONA D RADIOACTIVITY DETECTOR FOR HPLC.

COMPARATIVE IN VITRO METABOLISM OF T-2 TOXIN BY HEPATIC MICROSOMES PREPARED FROM PHENOBARBITOL-INDUCED OR CONTROL RATS, MICE, RABBITS, AND CHICKENS.

DEC 1986

Authors: C. A. KNUPP; S. P. SWANSON; W. B. BUCK; ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND FORT DETRICK MD

IN THIS STUDY THE IN VITRO METABOLISM OF T-2 TOXIN BY LIVER MICROSOMES, FORTIFIED WITH A NADPH GENERATING SYSTEM, PREPARED FROM THE RAT, RABBIT, MOUSE, AND CHICKEN WAS COMPARED. IN THE PRESENCE OF THE NADPH GENERATING SYSTEM, THE OXIDATION OF T-2 TOXIN BY MICROSOMAL PREPARATIONS COULD BE EVALUATED IN A MANNER SIMILAR TO EARLIER STUDIES COMPARING THE HYDROLYSIS OF THE ESTER GROUPS. METABOLIC PROFILES OBTAINED FROM CONTROL AND PHENOBARBITOL (PB) ...